1892581-29-1
1892581-29-1
Chemical Structure
Onfasprodil
Synonym(s): MIJ-821
- CAS No.: 1892581-29-1
- Formula:C20H23FN2O3
- Molecular Weight:358.41
IUPAC Name: 2-(butylamino)-1-(4-methoxyphenyl)-2-phenylethan-1-one hydrochloride
InChIKey: NEFQLCKWVRZEJA-ZDXGLAPJSA-N
SMILES: O[C@H](C1=CC=C(C=N1)O)CN(C2)C[C@](C3)([H])[C@@]2([H])C[C@H]3OC4=C(C=CC=C4)F
Biological Activity: Onfasprodil (MIJ-821) is a selective intravenous NMDA receptor NR2B subunit negative allosteric modulator (NAM). Onfasprodil inhibits the activity of NR2B-NMDA receptors. Onfasprodil has a rapid antidepressant effect. Onfasprodil can be used for the research of treatment-resistant depression (TRD)[1][2].
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Onfasprodil | Onfasprodil (MIJ-821) is a selective intravenous NMDA receptor NR2B subunit negative allosteric modulator (NAM). Onfasprodil inhibits the activity of NR2B-NMDA receptors. Onfasprodil has a rapid antidepressant effect. Onfasprodil can be used for the research of treatment-resistant depression (TRD). | |||||||||||||||||||||
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References
- [1]. Gomez-Mancilla B, et al. MIJ821 (onfasprodil) in healthy volunteers: First-in-human, randomized, placebo-controlled study (single ascending dose and repeated intravenous dose). Clin Transl Sci. 2023;16(11):2236-2252. [Content Brief]
- [2]. Shelton RC, et al. Rapid Onset and Sustained Efficacy of Onfasprodil (MIJ821), a Novel NR2B Negative Allosteric Modulator, in Patients With Treatment-Resistant Depression: A Phase 2, Randomized, Placebo-Controlled, Proof-of-Concept Study. J Clin Psychiatry. 2025 Aug 6;86(3):23m15246. [Content Brief]
