191421-10-0
Chemical Structure
5-NIdR
Synonym(s): 1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole
- CAS 番号: 191421-10-0
- Formula:C13H14N2O5
- Molecular Weight:278.26
IUPAC Name: (2R,3S,5R)-2-(hydroxymethyl)-5-(5-nitro-1H-indol-1-yl)tetrahydrofuran-3-ol
InChIKey: ODPRBLIUAVWXNM-YNEHKIRRSA-N
SMILES: O=[N+](C1=CC(C=CN2[C@@H]3O[C@H](CO)[C@@H](O)C3)=C2C=C1)[O-]
Biological Activity: 5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole), an artificial nucleoside, exhibits the ability to inhibit the replication of DNA lesions generated by Temozolomide (HY-17364). 5-NIdR induces cancer cells apoptosis and arrests cell cycle at G0 phase. 5-NIdR enhances Temozolomide anti-tumor efficacy in murine glioblastoma model[1].
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5-NIdR | 99.81% | 5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole), an artificial nucleoside, exhibits the ability to inhibit the replication of DNA lesions generated by Temozolomide (HY-17364). 5-NIdR induces cancer cells apoptosis and arrests cell cycle at G0 phase. 5-NIdR enhances Temozolomide anti-tumor efficacy in murine glioblastoma model. | ||||||||||||||||||||
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Keywords
