1918238-72-8
1918238-72-8
Chemical Structure
JAK 3i
- CAS No.: 1918238-72-8
- Formula:C18H15FN4O3
- Molecular Weight:354.34
IUPAC Name: ethyl 4-(5-acrylamido-2-fluorophenyl)-3H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
InChIKey: KNLROUBMVYVLGX-UHFFFAOYSA-N
SMILES: CCOC(C1=CN=C2C1=C(C3=C(F)C=CC(NC(C=C)=O)=C3)NC=N2)=O
Biological Activity: JAK3i is a highly selective JAK3 inhibitor (IC50: 0.43 nM). JAK3i forms a covalent bond with a cysteine in JAK3, but not the closely related kinase domains in JAK1, JAK2, or TYK2. JAK3i abolishes IL-2-driven T-cell proliferation in vivo and has the potential for autoimmune disease research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
JAK 3i | 99.81% | JAK3i is a highly selective JAK3 inhibitor (IC50: 0.43 nM). JAK3i forms a covalent bond with a cysteine in JAK3, but not the closely related kinase domains in JAK1, JAK2, or TYK2. JAK3i abolishes IL-2-driven T-cell proliferation in vivo and has the potential for autoimmune disease research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
