1940206-71-2
1940206-71-2
Chemical Structure
Dot1L-IN-2
- CAS No.: 1940206-71-2
- Formula:C27H24N8O
- Molecular Weight:476.53
IUPAC Name: N4-methyl-N2-(2-methyl-1-(2-((3-methyl-3H-imidazo[4,5-b]pyridin-6-yl)oxy)phenyl)-1H-indol-6-yl)pyrimidine-2,4-diamine
InChIKey: RQVLGMREYUFLPQ-UHFFFAOYSA-N
SMILES: CN1C=NC2=CC(OC3=CC=CC=C3N4C(C)=CC5=C4C=C(NC6=NC=CC(NC)=N6)C=C5)=CN=C21
Biological Activity: Dot1L-IN-2 is a potent, selective and orally bioavailable inhibitor of Dot1L (a histone methyltransferase), with an IC50 and Ki of 0.4 nM and 0.08 nM, respectively.
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Dot1L-IN-2 | Dot1L-IN-2 is a potent, selective and orally bioavailable inhibitor of Dot1L (a histone methyltransferase), with an IC50 and Ki of 0.4 nM and 0.08 nM, respectively. | |||||||||||||||||||||
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