1966932-74-0
Chemical Structure
KDM2/7-IN-2
- CAS No.: 1966932-74-0
- Formula:C25H30N2O2
- Molecular Weight:390.52
InChIKey: IVYXIZSSLAKIFL-HXOBKFHXSA-N
SMILES: CC[C@@H]1CCN(C[C@@H]1C(C2=CC3=CC=C(C(CC#N)=C3C=C2)OC)=O)C4CCC4
Biological Activity: KDM2A/7-IN-1 is a lysine demethylase 2A (KDM2A) inhibitor with a human IC50 of 11 nM. KDM2A/7-IN-1 requires co-factor 2-oxoglutarate (2OG) for binding and occupies the H3K36me2 substrate pocket via a dimethylated lysine 36-mimicking group. KDM2A/7-IN-1 represses E2F-regulated genes, induces epithelial-mesenchymal transition, DNA repair, and mTOR pathways in specific cells, and selectively inhibits proliferation of ALT-positive cancer cell lines. KDM2A/7-IN-1 can be used for the research of ALT-positive cancers[1].
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KDM2/7-IN-2 | KDM2A/7-IN-1 is a lysine demethylase 2A (KDM2A) inhibitor with a human IC50 of 11 nM. KDM2A/7-IN-1 requires co-factor 2-oxoglutarate (2OG) for binding and occupies the H3K36me2 substrate pocket via a dimethylated lysine 36-mimicking group. KDM2A/7-IN-1 represses E2F-regulated genes, induces epithelial-mesenchymal transition, DNA repair, and mTOR pathways in specific cells, and selectively inhibits proliferation of ALT-positive cancer cell lines. KDM2A/7-IN-1 can be used for the research of ALT-positive cancers. | |||||||||||||||||||||
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Keywords
