1971937-18-4
1971937-18-4
Chemical Structure
ARN19702
- CAS No.: 1971937-18-4
- Formula:C21H22FN3O3S2
- Molecular Weight:447.55
IUPAC Name: (S)-(2-(ethylsulfonyl)phenyl)(4-(6-fluorobenzo[d]thiazol-2-yl)-2-methylpiperazin-1-yl)methanone
InChIKey: UKQOLPNYRVPCBM-AWEZNQCLSA-N
SMILES: C[C@H]1CN(CCN1C(C2=C(C=CC=C2)S(CC)(=O)=O)=O)C(SC3=C4)=NC3=CC=C4F
Biological Activity: ARN19702 is a selective, orally active, reversible, and brain-penetrant N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 230 nM for human NAAA. ARN19702 has pain relief effects[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ARN19702 | 99.69% | ARN19702 is a selective, orally active, reversible, and brain-penetrant N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 230 nM for human NAAA. ARN19702 has pain relief effects. | ||||||||||||||||||||
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References
- [1]. Yannick Fotio, et al. Antinociceptive Profile of ARN19702, (2-Ethylsulfonylphenyl)-[(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone, a Novel Orally Active N-Acylethanolamine Acid Amidase Inhibitor, in Animal Models. J Pharmacol Exp Ther. 2021 Aug;378(2):70-76. [Content Brief]
- [2]. Marco Migliore Dr, et al. Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis. Angew Chem Int Ed Engl. 2016 Sep 5;55(37):11193-11197. [Content Brief]
