1977540-13-8
1977540-13-8
Chemical Structure
ONC213
- CAS No.: 1977540-13-8
- Formula:C23H22F2N4O
- Molecular Weight:408.44
InChIKey: JSJNWKZRWWDYBB-UHFFFAOYSA-N
SMILES: O=C1N(CC2=CC=C(F)C(F)=C2)C3=NCCN3C4=C1CN(CC4)CC5=CC=CC=C5
Biological Activity: ONC213 is an orally active αKGDH inhibitor. ONC213 can suppress mitochondrial respiration and elevate α-ketoglutarate levels by inhibiting αKGDH activity. ONC213 can induce cells apoptosis by inducing mitochondrial stress response and inhibiting translation of MCL-1. ONC213 can be used for the research of cancer, such as acute myeloid leukemia research (AML)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ONC213 | 99.86% | ONC213 is an orally active αKGDH inhibitor. ONC213 can suppress mitochondrial respiration and elevate α-ketoglutarate levels by inhibiting αKGDH activity. ONC213 can induce cells apoptosis by inducing mitochondrial stress response and inhibiting translation of MCL-1. ONC213 can be used for the research of cancer, such as acute myeloid leukemia research (AML). | ||||||||||||||||||||
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