1992047-63-8
1992047-63-8
Chemical Structure
M084 hydrochloride
- CAS No.: 1992047-63-8
- Formula:C11H16ClN3
- Molecular Weight:225.72
IUPAC Name: N-butyl-1H-benzo[d]imidazol-2-amine hydrochloride
InChIKey: DMLSYUAQEOLJQC-UHFFFAOYSA-N
SMILES: CCCCNC1=NC2=CC=CC=C2N1.Cl
Biological Activity: M084 hydrochloride is a TRPC4/5 channel blocker, with IC50 values of 10.3 μM and 8.2 μM, respectively. M084 hydrochloride has antidepressant and anxiolytic effects[1][2].
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M084 hydrochloride | M084 hydrochloride is a TRPC4/5 channel blocker, with IC50 values of 10.3 μM and 8.2 μM, respectively. M084 hydrochloride has antidepressant and anxiolytic effects. | |||||||||||||||||||||
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References
- [1]. Yang LP, et al. Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice. PLoS One. 2015 Aug 28;10(8):e0136255. [Content Brief]
- [2]. Zhu Y, et al. Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br J Pharmacol. 2015 Jul;172(14):3495-509. [Content Brief]
Keywords
