2002381-31-7
2002381-31-7
Chemical Structure
APS-2-79 hydrochloride
- CAS No.: 2002381-31-7
- Formula:C23H22ClN3O3
- Molecular Weight:423.89
IUPAC Name: 6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine hydrochloride
InChIKey: LIXKSHWZJNNZHG-UHFFFAOYSA-N
SMILES: CC1=CC(OC2=CC=CC=C2)=CC=C1NC3=C4C=C(OC)C(OC)=CC4=NC=N3.Cl
Biological Activity: APS-2-79 hydrochloride is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling[1].
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APS-2-79 hydrochloride | 98.42% | APS-2-79 hydrochloride is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling. | ||||||||||||||||||||
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