2027540-49-2
Chemical Structure
VPC-16606
- CAS No.: 2027540-49-2
- Formula:C17H13ClN2O2S
- Molecular Weight:344.81
IUPAC Name: (Z)-N-(2-chlorophenyl)-N'-(7-methyl-3-oxobenzo[b]thiophen-2(3H)-ylidene)acetohydrazide
InChIKey: KXLNYDWQXSNLPB-ZPHPHTNESA-N
SMILES: O=C1C(=NN(C(=O)C)C=2C=CC=CC2Cl)SC=3C1=CC=CC3C
Biological Activity: VPC-16606 is a selective inhibitor targeting the activation function 2 (AF2) domain of estrogen receptor α (ERα). VPC-16606 blocks the interaction between ERα and coactivators, inhibits the activity of both wild-type and clinically drug-resistant mutant ERα, and exerts inhibitory effects on hormone-resistant breast cancer cells. VPC-16606 can be used in breast cancer research[1].
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VPC-16606 | VPC-16606 is a selective inhibitor targeting the activation function 2 (AF2) domain of estrogen receptor α (ERα). VPC-16606 blocks the interaction between ERα and coactivators, inhibits the activity of both wild-type and clinically drug-resistant mutant ERα, and exerts inhibitory effects on hormone-resistant breast cancer cells. VPC-16606 can be used in breast cancer research. | |||||||||||||||||||||
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