204130-08-5
Chemical Structure
RWJ-60475
- CAS No.: 204130-08-5
- Formula:C13H11BrNO7P
- Molecular Weight:404.11
IUPAC Name: ((2-(4-bromophenoxy)-5-nitrophenyl)(hydroxy)methyl)phosphonic acid
InChIKey: JJKCSZKQYMYARX-UHFFFAOYSA-N
SMILES: OP(O)(C(C1=CC([N+]([O-])=O)=CC=C1OC2=CC=C(Br)C=C2)O)=O
Biological Activity: RWJ-60475 is a cell-permeable tyrosine phosphatase inhibitor with an IC50 of 3.3 μM. RWJ-60475, by inhibiting the activity of CD45/CD148 phosphatase, interferes with the phagocytic function of macrophages, thereby blocking the invasion of Legionella pneumophila into host cells and the transport of effector proteins. RWJ-60475 significantly reduces the uptake of bacterial particles by macrophages. RWJ-60475 can be used in the research of anti-infection targeting host factors[1][2].
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RWJ-60475 | RWJ-60475 is a cell-permeable tyrosine phosphatase inhibitor with an IC50 of 3.3 μM. RWJ-60475, by inhibiting the activity of CD45/CD148 phosphatase, interferes with the phagocytic function of macrophages, thereby blocking the invasion of Legionella pneumophila into host cells and the transport of effector proteins. RWJ-60475 significantly reduces the uptake of bacterial particles by macrophages. RWJ-60475 can be used in the research of anti-infection targeting host factors. | |||||||||||||||||||||
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References
- [1]. Charpentier X, et al. Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila. PLoS pathogens. 2009 Jul 3;5(7):e1000501.
- [2]. Karvinen J, et al. Fluorescence quenching-based assays for hydrolyzing enzymes. Application of time-resolved fluorometry in assays for caspase, helicase, and phosphatase. Anal Chem. 2004 Mar 1;76(5):1429-36. [Content Brief]
