2056261-42-6
Chemical Structure
BRD5648
Synonym(s): (R)-BRD0705
- CAS No.: 2056261-42-6
- Formula:C20H23N3O
- Molecular Weight:321.42
IUPAC Name: (R)-4-ethyl-7,7-dimethyl-4-phenyl-1,2,4,6,7,8-hexahydro-5H-pyrazolo[3,4-b]quinolin-5-one
InChIKey: NCKLQXXBRWCYMA-HXUWFJFHSA-N
SMILES: O=C1C2=C(N=C3C([C@@]2(CC)C4=CC=CC=C4)=CNN3)CC(C)(C)C1
Biological Activity: BRD5648 ((R)-BRD0705) is a negative control of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BRD5648 | 99.08% | BRD5648 ((R)-BRD0705) is a negative control of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML). | ||||||||||||||||||||
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Keywords
