2068806-31-3
2068806-31-3
Chemical Structure
EGFR-IN-99
- CAS No.: 2068806-31-3
- Formula:C25H22FN7O3
- Molecular Weight:487.49
IUPAC Name: 4-fluorobenzyl (3-acrylamidophenyl)(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)carbamate
InChIKey: IFRXGTCPIGRGHP-UHFFFAOYSA-N
SMILES: O=C(OCC1=CC=C(F)C=C1)N(C2=NC(NC3=CN(C)N=C3)=NC=C2)C4=CC=CC(NC(C=C)=O)=C4
Biological Activity: EGFR-IN-99 (compound 1a) is a potent EGFR and HER2 Exon 20 insertion mutant inhibitor. EGFR-IN-99 has excellent antiproliferative activity against DFCI127 cells, with an EC50 of 11.5 nM. EGFR-IN-99 can be used for the research of non-small cell lung cancer (NSCLC)[1].
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EGFR-IN-99 | 98.09% | EGFR-IN-99 (compound 1a) is a potent EGFR and HER2 Exon 20 insertion mutant inhibitor. EGFR-IN-99 has excellent antiproliferative activity against DFCI127 cells, with an EC50 of 11.5 nM. EGFR-IN-99 can be used for the research of non-small cell lung cancer (NSCLC). | ||||||||||||||||||||
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