2070009-62-8
Chemical Structure
Ivabradine-d6
- CAS No.: 2070009-62-8
- Formula:C27H30D6N2O5
- Molecular Weight:474.62
IUPAC Name: (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-bis(methoxy-d3)-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
InChIKey: ACRHBAYQBXXRTO-LTGPVEHVSA-N
SMILES: O=C1N(CCCN(C)C[C@@H]2C(C=C(OC)C(OC)=C3)=C3C2)CCC4=CC(OC([2H])([2H])[2H])=C(OC([2H])([2H])[2H])C=C4C1
Biological Activity: Ivabradine-d6 is the deuterium labeled Ivabradine[1]. Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity[2][3][4][5].
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Ivabradine-d6 | Ivabradine-d6 is the deuterium labeled Ivabradine. Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity. | |||||||||||||||||||||
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Ivabradine | 99.94% | Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Tardif JC, et al. Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina. Eur Heart J. 2005 Dec;26(23):2529-36. [Content Brief]
- [3]. Mulder P, et al. Heart rate slowing for myocardial dysfunction/heart failure. Adv Cardiol. 200643:97-105. [Content Brief]
- [4]. Cavalcante TMB, et al. Ivabradine possesses anticonvulsant and neuroprotective action in mice. Biomed Pharmacother. 2019 Jan109:2499-2512. [Content Brief]
- [5]. Du XJ, et al. I(f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities. Br J Pharmacol. 2004 May142(1):107-12. [Content Brief]
