207403-36-9
Chemical Structure
MR-16728 hydrochloride
- CAS No.: 207403-36-9
- Formula:C23H37ClN2O
- Molecular Weight:393.01
IUPAC Name: N-(3-(azepan-1-yl)propyl)-2-cyclohexyl-2-phenylacetamide hydrochloride
InChIKey: QLMQSFIGPVLVAO-UHFFFAOYSA-N
SMILES: O=C(NCCCN1CCCCCC1)C(C2CCCCC2)C3=CC=CC=C3.Cl
Biological Activity: MR-16728 hydrochloride is a compound that promotes the release of acetylcholine and has activity that enhances the release of acetylcholine. MR-16728 hydrochloride inhibits acetylcholine release induced by KCl depolarization. MR-16728 hydrochloride also inhibits Ca(2+)-ATPase activity in pure presynaptic membranes. The half-maximal effect of MR-16728 hydrochloride occurs at a concentration of 13.5 μM. MR-16728 hydrochloride significantly enhances the release of acetylcholine in the presence of low concentrations of calcium (approximately 10 μM range). Enhanced acetylcholine release was also observed with MR-16728 hydrochloride in proteoliposomes loaded with mediator proteins[1].
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MR-16728 hydrochloride | MR-16728 hydrochloride is a compound that promotes the release of acetylcholine and has activity that enhances the release of acetylcholine. MR-16728 hydrochloride inhibits acetylcholine release induced by KCl depolarization. MR-16728 hydrochloride also inhibits Ca(2+)-ATPase activity in pure presynaptic membranes. The half-maximal effect of MR-16728 hydrochloride occurs at a concentration of 13.5 μM. MR-16728 hydrochloride significantly enhances the release of acetylcholine in the presence of low concentrations of calcium (approximately 10 μM range). Enhanced acetylcholine release was also observed with MR-16728 hydrochloride in proteoliposomes loaded with mediator proteins. | |||||||||||||||||||||
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Keywords
