2077980-80-2
2077980-80-2
Chemical Structure
GLL398
- CAS No.: 2077980-80-2
- Formula:C25H23BO4
- Molecular Weight:398.26
IUPAC Name: (2E)-3-(4-(1-(4-boronophenyl)-2-phenylbut-1-en-1-yl)phenyl)acrylic acid
InChIKey: BINZFDGAOTWQNC-YGCRUXFTSA-N
SMILES: OC(/C=C/C(C=C1)=CC=C1/C(C2=CC=C(B(O)O)C=C2)=C(C3=CC=CC=C3)/CC)=O
Biological Activity: GLL398 is a potent, orally bioavailable selective estrogen receptor degrader (SERD) with an IC50 value of 1.14 nM. GLL398 shows a strong dose-dependent binding to ER with a mutation at Y537S (IC50=29.5 nM). GLL398 blocks tumor growth in xenograft models of breast cancer.
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GLL398 | GLL398 is a potent, orally bioavailable selective estrogen receptor degrader (SERD) with an IC50 value of 1.14 nM. GLL398 shows a strong dose-dependent binding to ER with a mutation at Y537S (IC50=29.5 nM). GLL398 blocks tumor growth in xenograft models of breast cancer. | |||||||||||||||||||||
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