2086229-19-6
Chemical Structure
FCW34
- CAS No.: 2086229-19-6
- Formula:C40H57N7O11
- Molecular Weight:811.92
IUPAC Name: (4-(3-(((3-((((3,5-dimethyl-2-(2-methyl-1-thiocarboxypropan-2-yl)phenoxy)carbonyl)oxy)methyl)-2-oxo-2H-chromen-7-yl)oxy)methyl)-4-nitrophenoxy)butyl)triphenylphosphonium
InChIKey: FOFWEYIPXRVWQC-XTRZVKHSSA-N
SMILES: O=C(O)C[C@H](NC1=CC=C([N+]([O-])=O)C2=NON=C21)C(O[C@@H]3CC[C@]4(C)[C@@]5([H])CC[C@]6(C)[C@@H]([C@@H](CCC(OCCOCCOCCN=[N+]=[N-])=O)C)CC[C@@]6([H])[C@]5([H])CC[C@]4([H])C3)=O
Biological Activity: FCW34 is a cell-permeable, selective Sialyltransferase inhibitor. FCW34 inhibits α2,3-N-linked ST3GALIII (IC50 1.74 μM) and α2,6-N-linked ST6GALI (IC50 3.6 μM), reducing N-glycoprotein sialylation. FCW34 decreases cell migration ability by inhibiting the Talin/Integrin/FAK/Paxillin and Integrin/NFκB signaling pathways. FCW34 significantly inhibits tumor growth, reduces angiogenesis, and suppresses spontaneous lung metastasis in a nude mouse model of breast cancer. FCW34 can be used for research on breast cancer[1].
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FCW34 | FCW34 is a cell-permeable, selective Sialyltransferase inhibitor. FCW34 inhibits α2,3-N-linked ST3GALIII (IC50 1.74 μM) and α2,6-N-linked ST6GALI (IC50 3.6 μM), reducing N-glycoprotein sialylation. FCW34 decreases cell migration ability by inhibiting the Talin/Integrin/FAK/Paxillin and Integrin/NFκB signaling pathways. FCW34 significantly inhibits tumor growth, reduces angiogenesis, and suppresses spontaneous lung metastasis in a nude mouse model of breast cancer. FCW34 can be used for research on breast cancer. | |||||||||||||||||||||
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