2097002-59-8
Chemical Structure
(R,S)-Selitrectinib
Synonym(s): (R,S)-LOXO-195
- CAS No.: 2097002-59-8
- Formula:C20H21FN6O
- Molecular Weight:380.42
IUPAC Name: (13E,14E,22R,6S)-35-fluoro-6-methyl-7-aza-1(5,3)-pyrazolo[1,5-a]pyrimidina-3(3,2)-pyridina-2(1,2)-pyrrolidinacyclooctaphan-8-one
InChIKey: OEBIHOVSAMBXIB-YVEFUNNKSA-N
SMILES: FC(C=C1[C@]2([H])N(CCC2)C3=NC4=C5C=NN4C=C3)=CN=C1CC[C@H](C)NC5=O
Biological Activity: (R,S)-Selitrectinib ((R,S)-LOXO-195) (compound 17) is a Trk inhibitor with activity against cancers harboring Trk inhibitor-resistant point mutations in NTRK1, NTRK2, or NTRK3 genes. (R,S)-Selitrectinib can be used for the research of trk inhibitor-resistant cancer[1].
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(R,S)-Selitrectinib | (R,S)-Selitrectinib ((R,S)-LOXO-195) (compound 17) is a Trk inhibitor with activity against cancers harboring Trk inhibitor-resistant point mutations in NTRK1, NTRK2, or NTRK3 genes. (R,S)-Selitrectinib can be used for the research of trk inhibitor-resistant cancer. | |||||||||||||||||||||
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Keywords
