2101700-14-3

(R)-Pirtobrutinib Chemical Structure
2101700-14-3

Chemical Structure

(R)-Pirtobrutinib

Synonym(s): (R)-LOXO-305

  • CAS No.: 2101700-14-3
  • Formula:C22H21F4N5O3
  • Molecular Weight:479.43

IUPAC Name: (R)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide

InChIKey: FWZAWAUZXYCBKZ-LLVKDONJSA-N

SMILES: O=C(C1=C(N)N([C@H](C)C(F)(F)F)N=C1C2=CC=C(CNC(C3=CC(F)=CC=C3OC)=O)C=C2)N

Biological Activity: (R)-Pirtobrutinib ((R)-LOXO-305) is a less active enantiomer of Pirtobrutinib. Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations[1].

Cat. No. Product Name Purity Description Pricing
HY-131328A
(R)-Pirtobrutinib 99.78% (R)-Pirtobrutinib ((R)-LOXO-305) is a less active enantiomer of Pirtobrutinib. Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations.
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