2110444-63-6
Chemical Structure
Boc-gly-PEG3-endo-BCN
- CAS No.: 2110444-63-6
- Formula:C28H47N3O8
- Molecular Weight:553.69
IUPAC Name: bicyclo[6.1.0]non-4-yn-9-ylmethyl tert-butyl (2-oxo-7,10,13-trioxa-3-azahexadecane-1,16-diyl)dicarbamate
InChIKey: SPXNLNQWLORDDS-UHFFFAOYSA-N
SMILES: O=C(OC(C)(C)C)NCC(NCCCOCCOCCOCCCNC(OCC1C2CCC#CCCC12)=O)=O
Biological Activity: Boc-gly-PEG3-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-gly-PEG3-endo-BCN is also a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Boc-gly-PEG3-endo-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
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Boc-gly-PEG3-endo-BCN | Boc-gly-PEG3-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-gly-PEG3-endo-BCN is also a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-gly-PEG3-endo-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | |||||||||||||||||||||
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References
- [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]
- [2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]
