2125955-70-4
2125955-70-4
Chemical Structure
PXS-5120A
- CAS No.: 2125955-70-4
- Formula:C22H25ClFN3O4S
- Molecular Weight:481.97
IUPAC Name: (Z)-1-(4-amino-2-fluorobut-2-en-1-yl)-3-(3-(N,N-dimethylsulfamoyl)phenyl)-2-methyl-1H-indole-5-carboxylic acid hydrochloride
InChIKey: PWSRWJMEGVKWES-WPTDRQDKSA-N
SMILES: O=C(C1=CC2=C(N(C/C(F)=C/CN)C(C)=C2C3=CC=CC(S(=O)(N(C)C)=O)=C3)C=C1)O.[H]Cl
Biological Activity: PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase-like 2/3 (LOXL2/3) with anti-fibrotic activity. PXS-5120A is >300-fold selective for LOXL2 (Ki of 83 nM; pIC50 of 8.4) over LOXL (pIC50 of 5.8)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PXS-5120A | 98.12% | PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase-like 2/3 (LOXL2/3) with anti-fibrotic activity. PXS-5120A is >300-fold selective for LOXL2 (Ki of 83 nM; pIC50 of 8.4) over LOXL (pIC50 of 5.8). | ||||||||||||||||||||
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References
Keywords
