2130846-15-8
Chemical Structure
HL2-m5
- CAS. Nr.: 2130846-15-8
- Formula:C70H101N15O24S3
- Molecular Weight:1632.83
SMILES: OC(C[C@@H](C(N)=O)NC([C@H]([C@H](O)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)CCC(O)=O)=O)C)=O)CCSC)=O)CC(O)=O)=O)CCSC)=O)CSCCOC2=CC=C(C=C2)C[C@@H]1NC([C@@H](NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H]([C@H](O)C)NC(C)=O)=O)=O)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O
Biological Activity: HL2-m5 is the inhibitor for the interaction between sonic hedgehog/patched (Shh/PTCH1) with Kd of 170 nM for Shh. HL2-m5 inhibits activation of Hedgehog signaling pathway and transcription of Gli-controlled gene with an IC50 of 230 nM[1].
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HL2-m5 | 97.22% | HL2-m5 is the inhibitor for the interaction between sonic hedgehog/patched (Shh/PTCH1) with Kd of 170 nM for Shh. HL2-m5 inhibits activation of Hedgehog signaling pathway and transcription of Gli-controlled gene with an IC50 of 230 nM. | ||||||||||||||||||||
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Keywords
