2135785-20-3
Chemical Structure
MAGL-IN-4
- CAS No.: 2135785-20-3
- Formula:C18H21ClN2O4
- Molecular Weight:364.82
IUPAC Name: (2s,4s)-2-(3-((3-chloro-4-methylbenzyl)oxy)azetidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one
InChIKey: AKBHYCHPWZPGAH-QGGXVJLZSA-N
SMILES: CC1=C(C=C(C=C1)COC2CN(C([C@H]3C[C@]4(COC(N4)=O)C3)=O)C2)Cl
Biological Activity: MAGL-IN-4 is an orally active, selective and reversible monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 6.2 nM. MAGL-IN-4 can penetrate the blood-brain barrier (BBB). MAGL-IN-4 enhances endocannabinoid signaling mostly by the increase in the level of 2-AG via selective MAGL inhibition in the brain[1].
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MAGL-IN-4 | 99.79% | MAGL-IN-4 is an orally active, selective and reversible monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 6.2 nM. MAGL-IN-4 can penetrate the blood-brain barrier (BBB). MAGL-IN-4 enhances endocannabinoid signaling mostly by the increase in the level of 2-AG via selective MAGL inhibition in the brain. | ||||||||||||||||||||
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Keywords
