2140807-58-3
2140807-58-3
Chemical Structure
JBJ-07-149
- CAS No.: 2140807-58-3
- Formula:C28H26N6O2S
- Molecular Weight:510.61
IUPAC Name: 2-(1-oxo-6-(6-(piperazin-1-yl)pyridin-3-yl)isoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide
InChIKey: HXPIITIHOKIXNN-UHFFFAOYSA-N
SMILES: O=C1C2=CC(C3=CC=C(N4CCNCC4)N=C3)=CC=C2CN1C(C5=CC=CC=C5)C(NC6=NC=CS6)=O
Biological Activity: JBJ-07-149 is an inhibitor for EGFRL858R/T790M with an IC50 of 1.1 nM. JBJ-07-149 inhibits the proliferation of cell Ba/F3 with IC50 of 4.9 μM and 0.148 μM, without and with presence of Cetuximab (HY-P9905). JBJ-07-149 can be used as ligand for target protein in synthesis of DDC-01-163 (HY-139997)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
JBJ-07-149 | 99.09% | JBJ-07-149 is an inhibitor for EGFRL858R/T790M with an IC50 of 1.1 nM. JBJ-07-149 inhibits the proliferation of cell Ba/F3 with IC50 of 4.9 μM and 0.148 μM, without and with presence of Cetuximab (HY-P9905). JBJ-07-149 can be used as ligand for target protein in synthesis of DDC-01-163 (HY-139997). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
