2170118-23-5
2170118-23-5
Chemical Structure
SN38-COOH
- CAS No.: 2170118-23-5
- Formula:C26H24N2O8
- Molecular Weight:492.48
IUPAC Name: (S)-4-((4,11-diethyl-9-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl)oxy)-4-oxobutanoic acid
InChIKey: AOWPNVSSWGMHGV-SANMLTNESA-N
SMILES: OC(CCC(O[C@]1(C2=C(COC1=O)C(N3C(C(C(C3)=C(C4=C5)CC)=NC4=CC=C5O)=C2)=O)CC)=O)=O
Biological Activity: SN38-COOH is used for the synthesis of antibody-drug conjugates (ADCs). SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
SN38-COOH | 98.57% | SN38-COOH is used for the synthesis of antibody-drug conjugates (ADCs). SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Wilson Lim, et al. Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma. PLoS Negl Trop Dis. 2018 Apr 26;12(4):e0006437. [Content Brief]
- [2]. Wallin A, et al. Anticancer effect of SN-38 on colon cancer cell lines with different metastatic potential. Oncol Rep. 2008 Jun;19(6):1493-8. [Content Brief]
