220339-00-4
Chemical Structure
N-Pentanoyl 2-benzyltryptamine
- CAS No.: 220339-00-4
- Formula:C22H26N2O
- Molecular Weight:334.45
IUPAC Name: N-(2-(2-benzyl-1H-indol-3-yl)ethyl)pentanamide
InChIKey: HDOIPCLEKCEANF-UHFFFAOYSA-N
SMILES: CCCCC(NCCC1=C(CC2=CC=CC=C2)NC3=C1C=CC=C3)=O
Biological Activity: N-Pentanoyl 2-benzyltryptamine is a potent and selective antagonist of MT2 melatonin receptor, with a pKi of 8.03 for human MT2. N-Pentanoyl 2-benzyltryptamine shows 89- and 229-fold selectivity for human MT2 over human mt1 and Xenopus mel1c receptor subtypes. N-Pentanoyl 2-benzyltryptamine can inhibit melatonin-induced enhancement of electrically-evoked responses[1][2].
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N-Pentanoyl 2-benzyltryptamine | 99.0% | N-Pentanoyl 2-benzyltryptamine is a potent and selective antagonist of MT2 melatonin receptor, with a pKi of 8.03 for human MT2. N-Pentanoyl 2-benzyltryptamine shows 89- and 229-fold selectivity for human MT2 over human mt1 and Xenopus mel1c receptor subtypes. N-Pentanoyl 2-benzyltryptamine can inhibit melatonin-induced enhancement of electrically-evoked responses. | ||||||||||||||||||||
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- [1]. Teh MT, et, al. Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores. Naunyn Schmiedebergs Arch Pharmacol. 1998 Nov;358(5):522-8. [Content Brief]
- [2]. Ting KN, et, al. Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats. Br J Pharmacol. 1999 Jun;127(4):987-95. [Content Brief]
Keywords
