220576-72-7
220576-72-7
Chemical Structure
EGFR-IN-451
- CAS No.: 220576-72-7
- Formula:C19H15N5O
- Molecular Weight:329.36
IUPAC Name: N-(4-((1H-indol-5-yl)amino)quinazolin-6-yl)acrylamide
InChIKey: ZEPDLDKXAUOXBS-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC2=C(N=CN=C2C=C1)NC3=CC4=C(C=C3)NC=C4)=O
Biological Activity: EGFR-IN-451 is an EGFR inhibitor with an IC50 value of 0.02 nM. EGFR-IN-451 also inhibits mutant EGFRL858R, EGFRT790M, and EGFRL858R/T790M with IC50 values of 0.26-34 nM. EGFR-IN-451 inhibits AKT and ERK activation and inhibits proliferation of EGFR-mutant cancer cells. EGFR-IN-451 can be used for the research of EGFR-driven cancer[1].
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EGFR-IN-451 | EGFR-IN-451 is an EGFR inhibitor with an IC50 value of 0.02 nM. EGFR-IN-451 also inhibits mutant EGFRL858R, EGFRT790M, and EGFRL858R/T790M with IC50 values of 0.26-34 nM. EGFR-IN-451 inhibits AKT and ERK activation and inhibits proliferation of EGFR-mutant cancer cells. EGFR-IN-451 can be used for the research of EGFR-driven cancer. | |||||||||||||||||||||
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