2223023-78-5
2223023-78-5
Chemical Structure
VUF14862
- CAS No.: 2223023-78-5
- Formula:C26H32N4O2
- Molecular Weight:432.56
IUPAC Name: (3-((E)-(4-((1r,3r)-3-(piperidin-1-yl)cyclobutoxy)phenyl)diazenyl)phenyl)(pyrrolidin-1-yl)methanone
InChIKey: LLWILWMTGDKHQL-PMSNSPATSA-N
SMILES: O=C(C1=CC=CC(/N=N/C2=CC=C(O[C@H]3C[C@H](N4CCCCC4)C3)C=C2)=C1)N5CCCC5
Biological Activity: VUF14862 is a stable and fatigue-resistant photoswitchable GPCR antagonist targeting the histamine H3 receptor (H3R) pathway. VUF14862 binds to H3R with >10-fold increased affinity upon 360 nm irradiation. VUF14862 can be used for spatiotemporal studies of H3R signaling[1].
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VUF14862 | VUF14862 is a stable and fatigue-resistant photoswitchable GPCR antagonist targeting the histamine H3 receptor (H3R) pathway. VUF14862 binds to H3R with >10-fold increased affinity upon 360 nm irradiation. VUF14862 can be used for spatiotemporal studies of H3R signaling. | |||||||||||||||||||||
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