2226303-74-6
Chemical Structure
Thalidomide-5-propargyl
- CAS No.: 2226303-74-6
- Formula:C16H12N2O5
- Molecular Weight:312.28
IUPAC Name: tert-butyl 3-(4-iodo-1H-pyrazol-1-yl)azetidine-1-carboxylate
InChIKey: GDWXJPQKRQMMQW-UHFFFAOYSA-N
SMILES: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(OCC#C)=C3)=O
Biological Activity: Thalidomide-5-propargyl is a propargyl-modified Thalidomide (HY-14658), that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-5-propargyl use alkynyl group at the end to be directly used in the synthesis of triazoles in the synthesis of PROTAC molecules, and is a key intermediate in the synthesis of PROTAC molecules based on CRBN design[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Thalidomide-5-propargyl | 95.87% | Thalidomide-5-propargyl is a propargyl-modified Thalidomide (HY-14658), that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-5-propargyl use alkynyl group at the end to be directly used in the synthesis of triazoles in the synthesis of PROTAC molecules, and is a key intermediate in the synthesis of PROTAC molecules based on CRBN design. | ||||||||||||||||||||
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Keywords
