2226664-93-1
Chemical Structure
KY19382
Synonym(s): A3051
- CAS No.: 2226664-93-1
- Formula:C17H11Cl2N3O2
- Molecular Weight:360.19
IUPAC Name: (2Z,3Z)-5',6'-dichloro-3-(methoxyimino)-[2,3'-biindolinylidene]-2'-one
InChIKey: PROTUMHDKVZVBW-CLXIBKRSSA-N
SMILES: O=C1NC2=C(C=C(Cl)C(Cl)=C2)/C1=C3NC4=C(C=CC=C4)C/3=N/OC
Biological Activity: KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases[1][2].
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KY19382 | 98.0% | KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases. | ||||||||||||||||||||
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- [1]. Choi S, et, al. CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth. Life Sci Alliance. 2019 Apr 10; 2(2): e201800254. [Content Brief]
- [2]. Choi KY, et, al. Compositions and methods for suppressing and/or treating metabolic diseases and/or a clinical condition thereof. WO2020079569.
Keywords
