2230826-81-8
Chemical Structure
PROTAC FLT-3 degrader 1
- CAS No.: 2230826-81-8
- Formula:C52H61N9O9S2
- Molecular Weight:1020.23
IUPAC Name: (2S,4R)-1-((S)-2-(3-(2-(2-((2-(4-(3-(5-(tert-butyl)isoxazol-3-yl)ureido)phenyl)benzo[d]imidazo[2,1-b]thiazol-7-yl)oxy)ethoxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChIKey: IKJBYQODYFQASC-YKCITUTQSA-N
SMILES: O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)CCOCCOCCOC4=CC5=C(N6C(S5)=NC(C7=CC=C(NC(NC8=NOC(C(C)(C)C)=C8)=O)C=C7)=C6)C=C4
Biological Activity: PROTAC FLT-3 degrader 1 is an effective and selective FLT-3 PROTAC degrader with an IC50 of 0.6 nM. PROTAC FLT-3 degrader 1 inhibits both FLT-3 and FLT-3 ITD mutants. PROTAC FLT-3 degrader 1 has the activity of anti-proliferation and induction of apoptosis, which can be used in the study of tumor[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PROTAC FLT-3 degrader 1 | 99.19% | PROTAC FLT-3 degrader 1 is an effective and selective FLT-3 PROTAC degrader with an IC50 of 0.6 nM. PROTAC FLT-3 degrader 1 inhibits both FLT-3 and FLT-3 ITD mutants. PROTAC FLT-3 degrader 1 has the activity of anti-proliferation and induction of apoptosis, which can be used in the study of tumor. | ||||||||||||||||||||
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