2231731-82-9
Chemical Structure
(E),(Z)-RNF5 agonist 1
- CAS No.: 2231731-82-9
- Formula:C22H18N4S
- Molecular Weight:370.47
InChIKey: SCPUGCLDMPNDGZ-CFPQKXLCSA-N
SMILES: CC1=NS/C(N1C2=CC=CC=C2)=N\C(C3=CC=CC=C3)=N\C4=CC=CC=C4
Biological Activity: (E),(Z)-RNF5 agonist 1 (Compound Analog-1) is a RNF5 agonist that can enhance the ubiquitination and degradation of SARS-CoV-2 E protein by RNF5. (E),(Z)-RNF5 agonist 1 effectively inhibits the replication of SARS-CoV-2 and significantly alleviates pulmonary pathological damage and systemic inflammatory response in mouse infection models. (E),(Z)-RNF5 agonist 1 has a strong cytotoxic effect on neuroblastoma and melanoma. (E),(Z)-RNF5 agonist 1 can be used for research on anti-cancer and anti-viral purposes[1].
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(E),(Z)-RNF5 agonist 1 | (E),(Z)-RNF5 agonist 1 (Compound Analog-1) is a RNF5 agonist that can enhance the ubiquitination and degradation of SARS-CoV-2 E protein by RNF5. (E),(Z)-RNF5 agonist 1 effectively inhibits the replication of SARS-CoV-2 and significantly alleviates pulmonary pathological damage and systemic inflammatory response in mouse infection models. (E),(Z)-RNF5 agonist 1 has a strong cytotoxic effect on neuroblastoma and melanoma. (E),(Z)-RNF5 agonist 1 can be used for research on anti-cancer and anti-viral purposes. | |||||||||||||||||||||
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