2243471-10-3
Chemical Structure
Procumbenoside I
- CAS No.: 2243471-10-3
- Formula:C26H24O12
- Molecular Weight:528.47
IUPAC Name: 9-(benzo[d][1,3]dioxol-5-yl)-7-hydroxy-6-methoxy-4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)naphtho[2,3-c]furan-1(3H)-one
InChIKey: DVCNMVLHFWGFJS-BKBOFEOXSA-N
SMILES: O=C1C2=C(C=3C(C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)=C2CO1)=CC(OC)=C(O)C3)C=5C=C6C(=CC5)OCO6
Biological Activity: Procumbenoside I is a naturally derived broad-spectrum antiviral agent targeting the SFTSV glycoprotein Gn. Procumbenoside I binds to the conserved B domain of SFTSV Gn, blocking the binding and internalization steps during viral entry. Procumbenoside I inhibits the entry of VSV, H5N1, and SARS-CoV-2 pseudoviral particles, while exhibiting antiviral activity against bunyaviruses such as LCMV and WELV. Procumbenoside I protects mice against lethal SFTSV challenge, reducing mortality and alleviating pathological damage. Procumbenoside I is useful for research related to viral infections[1][2][3][4].
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Procumbenoside I | Procumbenoside I is a naturally derived broad-spectrum antiviral agent targeting the SFTSV glycoprotein Gn. Procumbenoside I binds to the conserved B domain of SFTSV Gn, blocking the binding and internalization steps during viral entry. Procumbenoside I inhibits the entry of VSV, H5N1, and SARS-CoV-2 pseudoviral particles, while exhibiting antiviral activity against bunyaviruses such as LCMV and WELV. Procumbenoside I protects mice against lethal SFTSV challenge, reducing mortality and alleviating pathological damage. Procumbenoside I is useful for research related to viral infections. | |||||||||||||||||||||
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References
- [1]. Huang J, et al. Effectiveness of lignans against severe fever with thrombocytopenia syndrome virus infection. Virologica Sinica. 2026 Aug;41(4):912-922.
- [2]. Zhao Y, et al. Axial Chirality and Antiviral Activity Evaluation of Arylnaphthalene Lignan Glycosides from Justicia procumbens. Asian Journal of Organic Chemistry, 2022.
- [3]. Zhao Y. Axial chirality and antiviral activity evaluation of arylnaphthalene lignan glycosides from Justicia procumbens. Asian Journal of Organic Chemistry. 2022 Aug;11(8):e202200267.
- [4]. Guan L, et al. In-Depth Exploration of Chemical Constituents from Justicia procumbens L. Through UHPLC-Q-Exactive Orbitrap Mass Spectrometry. Molecules, 2025, 30: 3554.
