2249944-98-5
Chemical Structure
PROTAC MDM2 Degrader-1
- CAS No.: 2249944-98-5
- Formula:C74H84Cl4N10O13
- Molecular Weight:1463.33
IUPAC Name: N,N'-(((oxybis(ethane-2,1-diyl))bis(oxy))bis(propane-3,1-diyl))bis(2-(4-((4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamide)
InChIKey: AQFZQNOXRSZHMG-PQMVWXROSA-N
SMILES: O=C(N1CC(N(CC1)CC(NCCCOCCOCCOCCCNC(CN2C(CN(CC2)C(N3[C@@H](C4=CC=C(C=C4)Cl)[C@@H](C5=CC=C(C=C5)Cl)N=C3C6=C(C=C(C=C6)OC)OC(C)C)=O)=O)=O)=O)=O)N7[C@@H](C8=CC=C(C=C8)Cl)[C@@H](C9=CC=C(C=C9)Cl)N=C7C%10=C(C=C(C=C%10)OC)OC(C)C
Biological Activity: PROTAC MDM2 Degrader-1 (Compound 15a) is a MDM2 PROTAC degrader. The structures of both Linker ends of PROTAC MDM2 Degrader-1 are MDM2 ligands. PROTAC MDM2 Degrader-1 can not only block the binding of p53-MDM2, but also degrade the target MDM2 protein by utilizing the function of the E3 ligase of MDM2 itself, thus exerting an anti-tumor effect[1].
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PROTAC MDM2 Degrader-1 | 98.11% | PROTAC MDM2 Degrader-1 (Compound 15a) is a MDM2 PROTAC degrader. The structures of both Linker ends of PROTAC MDM2 Degrader-1 are MDM2 ligands. PROTAC MDM2 Degrader-1 can not only block the binding of p53-MDM2, but also degrade the target MDM2 protein by utilizing the function of the E3 ligase of MDM2 itself, thus exerting an anti-tumor effect. | ||||||||||||||||||||
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Keywords
