2259318-52-8
Chemical Structure
Mal-PEG4-VC-PAB-DMEA-PNU-159682
- CAS No.: 2259318-52-8
- Formula:C74H98N10O27
- Molecular Weight:1559.62
IUPAC Name: 4-((2S,5S)-25-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5-isopropyl-4,7,23-trioxo-2-(3-ureidopropyl)-10,13,16,19-tetraoxa-3,6,22-triazapentacosanamido)benzyl (2-oxo-2-((2S,4S)-2,5,12-trihydroxy-7-methoxy-4-(((1S,3R,4aS,9S,9aR,10aS)-9-methoxy-1-methyloctahydr
InChIKey: GIXBUAYRIIAYTE-QIBFXJAHSA-N
SMILES: C[C@H]1[C@]2([H])[C@](N3[C@]([C@H](OCC3)OC)([H])O2)([H])C[C@](O1)([H])O[C@@H]4C5=C(C[C@](C(COC(N(C)CCN(C)C(OCC6=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCNC(CCN7C(C=CC7=O)=O)=O)=O)=O)=O)C=C6)=O)=O)=O)(O)C4)C(O)=C8C(C(C9=C(OC)C=CC=C9C8=O)=O)=C5O
Biological Activity: Mal-PEG4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker Mal-PEG4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682[1].
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Mal-PEG4-VC-PAB-DMEA-PNU-159682 | 97.53% | Mal-PEG4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker Mal-PEG4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682. | ||||||||||||||||||||
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Keywords
