2260557-09-1
Chemical Structure
YCJ-02
- CAS No.: 2260557-09-1
- Formula:C23H19F2N3O3
- Molecular Weight:423.41
IUPAC Name: 2,3-difluoro-12-(2-(pyrrolidin-1-yl)ethyl)-[1,3]dioxolo[4',5':4,5]benzo[1,2-h]benzo[c][1,6]naphthyridin-13(12H)-one
InChIKey: OIQLIJSVFWDDGP-UHFFFAOYSA-N
SMILES: O=C1C2=CC(F)=C(C=C2C3=C(N1CCN4CCCC4)C5=CC6=C(OCO6)C=C5N=C3)F
Biological Activity: YCJ-02 is a selective Topoisomerase I (Top I) inhibitor. YCJ-02 can inhibit cell proliferation and induce apoptosis and G2/M phase arrest. YCJ-02 can induce DNA damage and increaseγ-H2AX levels. YCJ-02 can promote Top I deqradation via a ubiquitin/26S proteasome pathway. YCJ-02 increases the expressions of pro-apoptotic proteins Bad, Bax, and cleaved caspase-3. YCJ-02 shows broad-spectrum antitumor activity. YCJ-02 can be used for the research of cancer, such as intrahepatic cholangiocarcinoma (ICC)[1].
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YCJ-02 | YCJ-02 is a selective Topoisomerase I (Top I) inhibitor. YCJ-02 can inhibit cell proliferation and induce apoptosis and G2/M phase arrest. YCJ-02 can induce DNA damage and increaseγ-H2AX levels. YCJ-02 can promote Top I deqradation via a ubiquitin/26S proteasome pathway. YCJ-02 increases the expressions of pro-apoptotic proteins Bad, Bax, and cleaved caspase-3. YCJ-02 shows broad-spectrum antitumor activity. YCJ-02 can be used for the research of cancer, such as intrahepatic cholangiocarcinoma (ICC). | |||||||||||||||||||||
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Keywords
