2271348-04-8
2271348-04-8
Chemical Structure
MK256
- CAS No.: 2271348-04-8
- Formula:C14H9BrN2O2
- Molecular Weight:317.14
InChIKey: SNTFBMJZDZCZRU-UHFFFAOYSA-N
SMILES: O=C(C(C=CC1=C23)=CC1=CC(Br)=C3C=CN=C2N)O
Biological Activity: MK256 is an orally active, selective CDK8 inhibitor and CDK19/cyclin C inhibitor with IC50 values of 2.5 nM and 3.3 nM, respectively. MK256 downregulates phosphorylated STAT1 (S727), STAT5 (S726), MCL-1 mRNA and CCL2 mRNA. MK256 exhibits anti-tumor activity in acute myeloid leukemia. MK256 can be used for the research of acute myeloid leukemia[1].
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MK256 | MK256 is an orally active, selective CDK8 inhibitor and CDK19/cyclin C inhibitor with IC50 values of 2.5 nM and 3.3 nM, respectively. MK256 downregulates phosphorylated STAT1 (S727), STAT5 (S726), MCL-1 mRNA and CCL2 mRNA. MK256 exhibits anti-tumor activity in acute myeloid leukemia. MK256 can be used for the research of acute myeloid leukemia. | |||||||||||||||||||||
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References
Keywords
