2305355-56-8
2305355-56-8
Chemical Structure
Zilganersen
Synonym(s): ION373
- CAS No.: 2305355-56-8
- Formula:N/A
- Molecular Weight:7060.80
IUPAC Name: 3-(trifluoromethyl)isonicotinonitrile
SMILES: [Zilganersen]
Biological Activity: Zilganersen (ION373) is a gapmer antisense oligonucleotide targeting glial fibrillary acidic protein (GFAP). Zilganersen reduces excess glial fibrillary acidic protein produced by disease-causing variants in the GFAP gene and inhibits synthesis of GFAP. Zilganersen can be used for the research of Alexander disease[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zilganersen | 91.43% | Zilganersen (ION373) is a gapmer antisense oligonucleotide targeting glial fibrillary acidic protein (GFAP). Zilganersen reduces excess glial fibrillary acidic protein produced by disease-causing variants in the GFAP gene and inhibits synthesis of GFAP. Zilganersen can be used for the research of Alexander disease. | ||||||||||||||||||||
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References
- [1]. Jokūbas Leikauskas. Advances in enzymatic manufacturing, therapeutic pipelines, and regulatory pathways for nucleic acid therapeutics. Nucleic Acid Insights 2026; 3(1), 5-10.
- [2]. Alyssa C. Hill, et al. The MOE Modification of RNA: Origins and Widescale Impact on the Oligonucleotide Therapeutics Field. Helv. Chim. Acta 2023, 106, e202200169.
