2344825-52-9
Chemical Structure
XP-524
- CAS No.: 2344825-52-9
- Formula:C30H28N6O3S
- Molecular Weight:552.65
IUPAC Name: 2-(4-bromophenethyl)-1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrazine
InChIKey: LMLIBNUOIWAJFC-UHFFFAOYSA-N
SMILES: O=C1NC=CC2=C1N(C)C=C2C3=CC4=C(C=CN4C(C5=NC=CC=C5)(C)C6=NC=CC=C6)C(NS(=O)(CC)=O)=C3
Biological Activity: XP-524 is a potent BET and EP300 inhibitor. XP-524 shows great tumoricidal activity in vivo. XP-524 prevents KRAS-induced, neoplastic transformation in vivo and extends survival in two transgenic mouse models of aggressive PDAC. XP-524 also enhances the presentation of self-peptide and tumor recruitment of cytotoxic T lymphocytes. XP-524 has the potential for the research of pancreatic ductal adenocarcinoma (PDAC)[1].
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XP-524 | 98.02% | XP-524 is a potent BET and EP300 inhibitor. XP-524 shows great tumoricidal activity in vivo. XP-524 prevents KRAS-induced, neoplastic transformation in vivo and extends survival in two transgenic mouse models of aggressive PDAC. XP-524 also enhances the presentation of self-peptide and tumor recruitment of cytotoxic T lymphocytes. XP-524 has the potential for the research of pancreatic ductal adenocarcinoma (PDAC). | ||||||||||||||||||||
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