23567-96-6
Chemical Structure
8-Bromo-AMP
Synonym(s): 8-Bromoadenosine 5'-monophosphate; 8-Bromoadenylic acid
- CAS No.: 23567-96-6
- Formula:C10H13BrN5O7P
- Molecular Weight:426.12
IUPAC Name: ((2R,3S,4R,5R)-5-(6-amino-8-bromo-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate
InChIKey: DNPIJKNXFSPNNY-UUOKFMHZSA-N
SMILES: O=P(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C(Br)=NC3=C(N=CN=C32)N)O1)O)O)O
Biological Activity: 8-Bromo-AMP (8-Bromoadenosine 5'-monophosphate) is a membrane permeable cAMP analogue. 8-Bromo-AMP can improve the ability of the heart to recover from ischemia and reperfusion by increasing the levels of ATP, ADP, and total adenine nucleotides[1][2].
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8-Bromo-AMP | 98.78% | 8-Bromo-AMP (8-Bromoadenosine 5'-monophosphate) is a membrane permeable cAMP analogue. 8-Bromo-AMP can improve the ability of the heart to recover from ischemia and reperfusion by increasing the levels of ATP, ADP, and total adenine nucleotides. | ||||||||||||||||||||
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- [1]. Jiang J, et, al. Evidences for involvement of endogenous cAMP in Arabidopsis defense responses to Verticillium toxins. Cell Res. 2005 Aug;15(8):585-92. [Content Brief]
- [2]. Nakai T, et, al. Effects of adenine nucleotide analogues on myocardial dysfunction during reperfusion after ischemia in dogs. J Cardiovasc Pharmacol. 1996 Aug;28(2):264-70. [Content Brief]
Keywords
