2361799-64-4
2361799-64-4
Chemical Structure
DPTIP hydrochloride
- CAS No.: 2361799-64-4
- Formula:C21H19ClN2O3S
- Molecular Weight:414.91
InChIKey: JXCSNAONSJHTTR-UHFFFAOYSA-N
SMILES: OC1=C(OC)C=C(C2=NC(C3=CC=CC=C3)=C(C4=CC=CS4)N2)C=C1OC.Cl
Biological Activity: DPTIP hydrochloride is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM[1][2].
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DPTIP hydrochloride | DPTIP hydrochloride is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM. | |||||||||||||||||||||
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References
- [1]. Camilo Rojas, et al. DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci Rep. 2018 Dec 7;8(1):17715. [Content Brief]
- [2]. Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330. [Content Brief]
Keywords
