2374274-85-6
2374274-85-6
Chemical Structure
IR-58
- CAS No.: 2374274-85-6
- Formula:C58H82BrClN4O6
- Molecular Weight:1046.65
InChIKey: BMRWNJCATBASDR-UHFFFAOYSA-N
SMILES: O=C(CNC(CCCCCCCCCCN1C2=C(C(C)(C)/C1=C/C=C3C(Cl)=C(CCC/3)/C=C/C4=[N+](CCCCCCCCCCC(NCC(OC)=O)=O)C5=C(C4(C)C)C=CC=C5)C=CC=C2)=O)OC.[Br-]
Biological Activity: IR-58, a mitochondria-targeting near-infrared (NIR) fluorophore, is an autophagy enhancer. IR-58 kills tumour cells and induces apoptosis via inducing excessive autophagy, which is mediated through the reactive oxygen species (ROS)-Akt-mTOR pathway[1].
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IR-58 | IR-58, a mitochondria-targeting near-infrared (NIR) fluorophore, is an autophagy enhancer. IR-58 kills tumour cells and induces apoptosis via inducing excessive autophagy, which is mediated through the reactive oxygen species (ROS)-Akt-mTOR pathway. | |||||||||||||||||||||
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