2378606-21-2
Chemical Structure
OPBP-1
- CAS No.: 2378606-21-2
- Formula:C64H92N20O19S
- Molecular Weight:1477.60
InChIKey: ZBDTUWHAABRPDJ-XHSFAGHPSA-N
SMILES: O=C(N[C@H](CCC(N)=O)C(N[C@H](CO)C(N[C@H](CCC(O)=O)C(N[C@H](CC1=CNC=N1)C(N[C@H](CC2=CNC=N2)C(N[C@H](CCSC)C(N[C@H](CCCNC(N)=N)C(N[C@H](C(C)C)C(N[C@H](CC3=CC=C(C=C3)O)C(N[C@H](CO)C(N[C@H](CC4=CC=CC=C4)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
Biological Activity: OPBP-1 is a D-peptide obtained by phage display screening, molecular docking and molecular dynamics simulation. OPBP-1 has high stability and strong antitumor and oral activity. OPBP-1 can selectively bind PD-L1 protein, significantly block the interaction between PD-1 and PD-L1, and this blocking effect helps to restore and improve the function of T lymphocytes and reduce the proportion of bone marrow derived suppressor cells (MDSCs) to combat tumor-induced immune escape. OPBP-1 can be used in cancer immunotherapy research[1].
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OPBP-1 | 99.88% | OPBP-1 is a D-peptide obtained by phage display screening, molecular docking and molecular dynamics simulation. OPBP-1 has high stability and strong antitumor and oral activity. OPBP-1 can selectively bind PD-L1 protein, significantly block the interaction between PD-1 and PD-L1, and this blocking effect helps to restore and improve the function of T lymphocytes and reduce the proportion of bone marrow derived suppressor cells (MDSCs) to combat tumor-induced immune escape. OPBP-1 can be used in cancer immunotherapy research. | ||||||||||||||||||||
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Keywords
