2379556-15-5
Chemical Structure
TH9028
- CAS No.: 2379556-15-5
- Formula:C16H18N12O5
- Molecular Weight:458.39
InChIKey: PMGGZFQJUNWXHA-QMMMGPOBSA-N
SMILES: NC(NC(N)=NC1=O)=C1NC(NC2=CN=C(C(N[C@H](C(O)=O)CCC3=NN=NN3)=O)C=C2)=O
Biological Activity: TH9028 is an inhibitor of MTHFD1, MTHFD2 and MTHFD2L, with IC50 values of 0.5 nM, 11 nM and 27 nM, respectively. TH9028 reduces replication fork speed, induces replication stress, triggers S-phase arrest, initiates apoptosis, impairs thymidine production, and causes erroneous uracil incorporation into DNA. TH9028 can be used in research related to acute myeloid leukemia[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TH9028 | TH9028 is an inhibitor of MTHFD1, MTHFD2 and MTHFD2L, with IC50 values of 0.5 nM, 11 nM and 27 nM, respectively. TH9028 reduces replication fork speed, induces replication stress, triggers S-phase arrest, initiates apoptosis, impairs thymidine production, and causes erroneous uracil incorporation into DNA. TH9028 can be used in research related to acute myeloid leukemia. | |||||||||||||||||||||
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- [1]. Jha V, et al. Selectivity analysis of diaminopyrimidine-based inhibitors of MTHFD1, MTHFD2 and MTHFD2L. Sci Rep. 2024;14(1):21073. Published 2024 Sep 10. [Content Brief]
- [2]. Bonagas N, et al. Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nat Cancer. 2022;3(2):156-172. [Content Brief]
Keywords
