2403600-07-5
Chemical Structure
HPK1-IN-17
- CAS No.: 2403600-07-5
- Formula:C26H28N6O
- Molecular Weight:440.54
IUPAC Name: N,N-dimethyl-4-(2-(4-(4-methylpiperazin-1-yl)phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)benzamide
InChIKey: UGFRQKYVEWFPGO-UHFFFAOYSA-N
SMILES: O=C(N(C)C)C1=CC=C(C2=CNC3=C2N=C(C4=CC=C(N5CCN(CC5)C)C=C4)C=N3)C=C1
Biological Activity: HPK1-IN-17 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-17 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2019238067A1, compound 73)[1].
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HPK1-IN-17 | HPK1-IN-17 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-17 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2019238067A1, compound 73). | |||||||||||||||||||||
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