2409793-36-6
Chemical Structure
PROTAC EGFR degrader 5
- CAS No.: 2409793-36-6
- Formula:C57H72FN13O5S
- Molecular Weight:1070.33
IUPAC Name: (R)-N-(1-(3-(1H-pyrrolo[2,3-c]pyridin-1-yl)propanoyl)piperidin-4-yl)-2-amino-2-phenylacetamide
InChIKey: LCTCXOPSLJEXKE-FEDPBZRBSA-N
SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCN4CCN(CC4)C5=CC=C(N=C5)NC6=NC=C7N=C(N=C(C7=C6)N8CCC(CC8)CO)NC9=CC=C(C=C9)F)=O)=O)O)=O
Biological Activity: PROTAC EGFR degrader 5 (Compound 10), a PROTAC EGFR degrader, potently degrades EGFRDel19 in HCC827 cells with the DC50 of 34.8 nM. PROTAC EGFR degrader 5 significantly induces the apoptosis of HCC827 cells and arrest the cells in G1 phase[1].
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PROTAC EGFR degrader 5 | PROTAC EGFR degrader 5 (Compound 10), a PROTAC EGFR degrader, potently degrades EGFRDel19 in HCC827 cells with the DC50 of 34.8 nM. PROTAC EGFR degrader 5 significantly induces the apoptosis of HCC827 cells and arrest the cells in G1 phase. | |||||||||||||||||||||
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Keywords
