2416910-88-6
Chemical Structure
MAO-B-IN-9
- CAS No.: 2416910-88-6
- Formula:C18H24N2O2
- Molecular Weight:300.40
IUPAC Name: 1-(prop-2-yn-1-yl)piperidin-4-yl (4-isopropylphenyl)carbamate
InChIKey: LJYBWYFQBIECKG-UHFFFAOYSA-N
SMILES: C#CCN1CCC(CC1)OC(NC2=CC=C(C=C2)C(C)C)=O
Biological Activity: MAO-B-IN-9 (compound 16) is a potent, selective, BBB-penetrated, irreversible and time-dependent MAO-B (monoamine oxidase B) inhibitor, with an IC50 of 0.18 μM. MAO-B-IN-9 prevents Aβ1-42-induced neuronal cell death. MAO-B-IN-9 shows neuroprotective effects, which may be the result of its Aβ1-42 anti-aggregation effects[1]. MAO-B-IN-9 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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MAO-B-IN-9 | 99.70% | MAO-B-IN-9 (compound 16) is a potent, selective, BBB-penetrated, irreversible and time-dependent MAO-B (monoamine oxidase B) inhibitor, with an IC50 of 0.18 μM. MAO-B-IN-9 prevents Aβ1-42-induced neuronal cell death. MAO-B-IN-9 shows neuroprotective effects, which may be the result of its Aβ1-42 anti-aggregation effects. MAO-B-IN-9 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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Keywords
