2421135-03-5
2421135-03-5
Chemical Structure
TGFβRI-IN-4
- CAS No.: 2421135-03-5
- Formula:C23H25F2N5O2
- Molecular Weight:441.47
IUPAC Name: 2-(4-((4-((1-cyclopropyl-3-(3,3-difluorocyclobutyl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol
InChIKey: MVQOWTPMVHJPMY-UHFFFAOYSA-N
SMILES: CC(O)(C1=CC(NC2=CC(OC3=CN(N=C3C4CC(F)(C4)F)C5CC5)=CC=N2)=CC=N1)C
Biological Activity: TGFβRI-IN-4 is a highly potent and orally active TGFβ receptor type I (TGFβRI) inhibitor, with IC50s of 44 nM and 42.5 nM for ALK5 and NIH3T3. TGFβRI-IN-4 can suppress tumor growth and tumor weight in tumor xenograft model[1].
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TGFβRI-IN-4 | TGFβRI-IN-4 is a highly potent and orally active TGFβ receptor type I (TGFβRI) inhibitor, with IC50s of 44 nM and 42.5 nM for ALK5 and NIH3T3. TGFβRI-IN-4 can suppress tumor growth and tumor weight in tumor xenograft model. | |||||||||||||||||||||
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