2445840-25-3
2445840-25-3
Chemical Structure
FSI-TN42
Synonym(s): N42
- CAS No.: 2445840-25-3
- Formula:C24H31Cl2N5O2
- Molecular Weight:492.44
InChIKey: XWZXUMZNZGHQGY-UHFFFAOYSA-N
SMILES: O=C(N1CCN(CC1)C2=CC=C(C(N3CCCCCC3)=C2)NC(C(Cl)Cl)=O)C4=CC=CN4C
Biological Activity: FSI-TN42 (N42) is a selective, orally active and irreversible ALDH1A1 inhibitor with an IC50 of 23 nM. FSI-TN42 shows 800-fold more potent against ALDH1A1 than ALDH1A2 (IC50[1][2].
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FSI-TN42 | 98.05% | FSI-TN42 (N42) is a selective, orally active and irreversible ALDH1A1 inhibitor with an IC50 of 23 nM. FSI-TN42 shows 800-fold more potent against ALDH1A1 than ALDH1A2 (IC50 | ||||||||||||||||||||
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References
- [1]. Paik J, et al. Weight loss and metabolic effects of an ALDH1A1-specific inhibitor, FSI-TN42, in a diet induced mouse model of obesity. Int J Obes (Lond). 2025 Mar;49(3):507-515. [Content Brief]
- [2]. Haenisch M, et al. Investigation of an ALDH1A1-specific inhibitor for suppression of weight gain in a diet-induced mouse model of obesity. Int J Obes (Lond). 2021 Jul;45(7):1542-1552. [Content Brief]
Keywords
