2453228-45-8
Chemical Structure
Anticancer agent 71
- CAS No.: 2453228-45-8
- Formula:C18H13ClF3N5O
- Molecular Weight:407.78
IUPAC Name: 1-(2-amino-6-phenylpyrimidin-4-yl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
InChIKey: HQDVZDXIFMCLAZ-UHFFFAOYSA-N
SMILES: NC1=NC(NC(NC2=CC=C(C(C(F)(F)F)=C2)Cl)=O)=CC(C3=CC=CC=C3)=N1
Biological Activity: Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity[1].
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Anticancer agent 71 | Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity. | |||||||||||||||||||||
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Keywords